SHHRKS (Shark–Human Holistic Research & Knowledge System) is a transdisciplinary, multispecies, and relational-systems framework for understanding and engaging with human–shark interactions in marine contact zones. Emerging from long-term fieldwork in New Zealand and the Sundarbans, SHHRKS responds to the fragmentation of shark research across natural sciences, social sciences, and the humanities, where sharks and humans are often studied in isolation despite their entangled lives. Situated within the Blue Humanities, the framework reorients inquiry toward oceanic relationality and fluid socio-ecological systems. SHHRKS integrates three core pillars: a multispecies perspective that recognizes humans and sharks as co-constitutive agents; a transdisciplinary approach that brings together scientific, local, cultural, and artistic knowledge systems; and a relational-systems orientation informed by assemblage thinking, Actor–Network Theory, and systems theory. It further advances a trans-knowledge and multimodal approach, incorporating quantitative, qualitative, and sensory modes of knowing and communication. Such an approach may be applied  to both negative and positive human–shark interactions, reframing “conflict” as an emergent property of broader socio-ecological assemblages shaped by environmental change, economic pressures, and cultural narratives. It also examines how shark imagery and affect influence conservation outcomes, arguing that transforming perception requires engagement beyond scientific data, including artistic and experiential modalities. Drawing on field-based interventions, the chapter demonstrates how SHHRKS translates integrated knowledge into context-sensitive action through community engagement, cultural practices, and participatory conservation strategies. Ultimately, SHHRKS proposes a holistic and action-oriented model for rethinking human–shark relations and advancing more inclusive and sustainable forms of multispecies coexistence.